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KMID : 0880220070450030275
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Journal of Microbiology
2007 Volume.45 No. 3 p.275 ~ p.279
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Burkholderia cepacia Complex Infection in a Cohort of Italian Patients with Cystic Fibrosis
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Lambiase Antonietta
Raia Valeria
Stefani Stefania
Sepe Angela
Ferri Pasqualina
Buonpensiero Paolo
Rossano Fabio
Pezzo Mariassunta Del
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Abstract
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The aims of this study were to detect Burkholderia cepacia complex (Bcc) strains in a cohort of Cystic Fibrosis patients (n=276) and to characterize Bcc isolates by molecular techniques. The results showed that 11.23% of patients were infected by Bcc. Burkholderia cenocepacia lineage III-A was the most prevalent species (64.3%) and, of these, 10% was cblA positive and 50% esmR positive. Less than half of the strains were sensitive to ceftazidime, meropenem, piperacillin tazobactam, and trimethoprim-sulfamethoxazole. About half of the strains (41%) had homogeneous profiles, suggesting cross-transmission. The infection by B. cenocepacia was associated to a high rate of mortality (p=0.01).
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KEYWORD
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cystic fibrosis, Burkholderia cepacia complex, rec-A gene, PFGE
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